Your doctor may have talked to you about whether testosterone therapy is right for you. Here’s some information about testosterone therapy, what it does and how to take it.
What is testosterone therapy?
Testosterone is a hormone (or chemical messenger) made in your ovaries and also your adrenal glands, which are small glands near your kidneys. Levels of testosterone in your body gradually reduce as you become older. This gradual reduction does not accelerate in the menopause transition. Levels reduce very abruptly when you have had an oophorectomy (an operation in which your ovaries are removed). When your testosterone levels reduce you may find that you desire sex less often, and when you do have sex, it is not as pleasurable as it used to be, even though you still desire your partner.
Loss of sexual desire (libido) can be caused by many different medical and psychological conditions and medications (including commonly prescribed antidepressants). Stress and life events can also have an impact. Low levels of hormones of the type called androgens may be just one of the factors leading to your loss of libido with the menopause symptoms you’re experiencing. As testosterone is an androgen, testosterone therapy may be offered to help boost your libido if this has not improved with hormone replacement therapy (HRT). Other support may be recommended instead of testosterone, such as psychosexual or relationship counselling.
You may experience uncomfortable and painful intercourse as a result of menopause related vaginal and vulval changes.
It is important that these symptoms are addressed before testosterone is trialled. Your doctor can prescribe vaginal oestrogens in addition to hormone replacement therapy. Lubricants and vaginal moisturisers can be helpful also.
Not everyone with a low level of testosterone will have a low libido. A low level of testosterone does not mean that it needs replacing. There is no good evidence that taking testosterone will help improve low mood, cognitive function (such as brain fog) or low energy levels.
What are the benefits of testosterone therapy?
Replacing testosterone can increase sexual desire and pleasure for some, but not everyone.
Are there any risks to testosterone therapy?
Studies to date suggest that there’s no increased risk of heart disease, breast cancer or stroke in the short term, but we don’t have studies that tell us about the long-term risks and safety of testosterone therapy.
How to take testosterone therapy
Testosterone gel is available in the UK on NHS prescriptions for off license prescribing, or cream which is only available privately. Testosterone prescribing in many areas of the UK has to be initiated by a specialist.
In the UK testosterone gel isn’t licensed for use in women, only men, but is often prescribed off-licence for women who are already taking HRT. It’s use is also endorsed by the National Institute of Clinical Excellence Guidelines on the menopause NG 23 2015.
Testosterone gel or cream is applied to the skin so that it goes directly into your bloodstream. The doses used in women are much lower than those used for men. The aim is to keep the testosterone at a level that’s not greater than those found before menopause.
It may take 3-6 months to feel any benefit from taking testosterone. If there has been no benefit in that time, we would advise you to stop using it.
What is off license prescribing?
Before a medicine can be used in the UK, it must be granted a licence. While all medicines and treatments have side-effects and risks, a licence tells you that all the proper checks have been done and the benefits of the medicine are believed to outweigh the risks. The licence states what conditions the medicine has been approved to treat.
When a treatment is used off-licence, it means that the medicine has a licence, but it’s not for the condition that you have. In other words, testosterone has not undergone the required, regulated clinical trials to see if it’s effective and safe in treating your condition. But that doesn’t mean it’s unsafe, and it doesn’t mean it won’t work.
There are a number of reasons why a medicine may be unlicensed in the UK. For example, it may be waiting for a licence to be granted, or the need for the medicine may be so small that it doesn’t make commercial sense for the manufacturer to pay for the relevant testing.
The different types of testosterone available
off-licence in the UK, and how to use them, are outlined below:
- TESTOGELTM (Besins Healthcare Ltd UK) – 40.5mg in 2.5g sachets. Use a small, pea-sized amount and rub it into the front of the thigh every day changing the site of application to avoid extra hair growth. The sachet should last around 8 days to give a dose of 5mg a day. You can fold over the open top of the sachet and clip it closed with a bag clip.
- TOSTRAN GELTM (Kyowa Kirin Ltd) – 20mg in 1g. One press delivers 10mg of testosterone. Use 1 press of gel 2 to 3 times a week. If you use it every day the dose will be too high. Don’t apply the gel to the same patch of skin every time. Change the site of application to avoid additional hair growth at application sites.
- ANDROFEMMETM (Lawley Pharm) – 1% testosterone cream in 50ml tube. Starting dose is 0.5mls per day (5mg testosterone a day). Only available privately.
What are the side effects of testosterone therapy?
The most common side effects are skin changes, such as acne, increased greasiness of the hair and thicker body hair or excess hair.
Androgenic side effects include acne and, rarely, virilisation (voice deepening and an enlarged clitoris). Other rare side effects include hair loss, excessive hairiness, fluid retention, increase in muscle mass, weight gain, nausea, headaches, mood changes, jaundice, and an increase in cholesterol.
Side effects are generally only seen when high doses of testosterone are given. If you experience side effects reducing the dose or else stopping treatment altogether may help. Please contact the clinic if you have any concerns.
Risk of testosterone transfer to others
During close and relatively long periods of skin contact testosterone may be transferred to another person unless you cover the treated area. Transfer can potentially result in the other person showing signs of increased testosterone – masculinisation effects as described n the side effects above.
Wearing clothes covering the application area or washing the application area before contact protects against such transfer. The following precautions are recommended:
For the patient:
- Wash your hands with soap and water after applying the gel,
- Cover the application area with clothing once the gel has dried,
- Wash the application area before making close contact with another person.
If you believe testosterone has been transferred to another person (adult or child), this person should:
- Wash the area of skin onto which may have been affected immediately with soap and water and report any signs such as acne or changes in the growth or pattern of hair on the body or face to their doctor.
Important
You should preferably wait at least 1 hour before showering or bathing after applying the testosterone gel.
Informed Consent
This leaflet is provided to supplement verbal information that will be given to you by your healthcare provider (Doctor/ Surgeon/ Nurse) as part of the consent process prior to your procedure. Information sharing between you and the clinician is essential to ensure that your decision to consent is fully informed.
Please ask questions if you don’t fully understand or have any concerns about what is proposed. You have a right to be involved in these decisions and should feel supported to do so. Please take the time to consider what is important to you to ensure the information you receive is specific and individualised.