Combined test performed in the first trimester between 11 weeks 2 days to 14 weeks 1 day of gestation to assess the chance of Down’s syndrome (T21) and/or Edwards’/ Patau’s syndrome (T18/T13). The laboratory measures free beta human chorionic gonadotrophin (free beta HCG) and pregnancy associated plasma protein-A (PAPP-A).
Quadruple test performed in the second trimester between 14 weeks 2 days to 20 weeks 0 days gestation to assess the chance of T21 only. The laboratory measures alpha fetoprotein (AFP), free beta human chorionic gonadotrophin (free beta HCG), unconjugated oestriol (uE3) and Inhibin-A.
Tube
Serum Gel
ID
29949
Availability
Weekdays
Send to
Specialist Laboratory Medicine
Block 46
St James hospital
Beckett Street
Ä¢¹½tvÊÓƵ
LS9 7TF
Contact
For further details please contact Ä¢¹½tvÊÓƵ Pathology customer services: [email protected].
Advice
Visit the
Collection Con
Minimum volume: 2 mL
Instructions for lab: On receipt of samples, they should be centrifuged (and separated if a non-gel tube is received). Send to Block 46. If storage required (overnight or over the weekend) store refrigerated at 2 to 8°C.
Aliquots (when required) should be appropriately labelled according to the Pathology labelling policy.
Screening sample stability acceptance criteria:
Whole blood (unseparated) samples can be stored at:
- Room temperature (20 degrees Celsius) for 48 hours
- 4 degrees Celsius for 5 days
Serum (separated) samples can be stored at:
- Room temperature (20 degrees Celsius) for 72 hours
- 4 degrees Celsius for 14 days
Frequency
Daily
Sample REQ
Serum
Ref. Range Notes
The results of the biochemistry tests are combined with scan and demographic data in a software program to calculate the risk of the pregnancy being affected by Down’s syndrome, Edward’s syndrome and Patau’s syndrome.