Idiopathic inflammatory myopahies are an inflammatory disease of skeletal muscles. These myopathies can be divided into polymyositis, dermatomyositis, idiopathic myositis, anti-synthetase syndrome and overlap syndrome.
Tube
Serum Gel
ID
12789
Additional Information
This assay detects autoantibodies to 11 different myositis associated antigens: Jo-1, Mi-2alpha and Mi-2beta, TIF1gamma (transcriptional intermediary factor), MDA5 (melanoma differentiation-associated gene 5), XNP2, SAE (SAE1/2), Ku, PM-Scl100, PM-Scl75, SRP (signal recognition particle), PL-7, PL-12, EJ. OJ and Ro-52. Anti-Jo-1 Ab are found in polymyositis, often occur simultaneously in autoimmune diseases such as SLE, systemic sclerosis or interstitial lung fibrosis. Mi-2 Ab are highly specific for dermatomyositis. Anti- Jo-1, PL-7, PL-12 EJ and OJ antibodies are associated with anti-synthetase syndrome. Anti-SRP Ab is a marker for immune-mediated necrotising myopathy. Anti-PM-Scl 75 and 100 Ab are associated with overlap syndrome which manifests as a combination of polymyositis, dermatomyoitis and systemic sclerosis symptoms. Anti-Ro52 Ab are not associated with a specific disease, but can be found in both autoimmune and infectious diseases.
Send to
Ä¢¹½tvÊÓƵ General Infirmary
Clinical Immunology
Old Medical School
Great George Street
Ä¢¹½tvÊÓƵ
LS1 3EX
Frequency
Every fortnight
Sample REQ
Blood
Ref. Range (Male)
N/A – Interpretive
Ref. Range (Female)
N/A – Interpretive
Ref. Range (Paed)
N/A – Interpretive
Ref. Range Notes
Positive/Negative
Units
N/A
IP Acute TAT
Contact Laboratory
IP Routine TAT
Due to extended service pressures please note our TAT have been temporarily extended by 6 weeks beyond the times stated above/below. Please do not contact the lab before this time frame unless there is a clinically urgent need.
GP Acute TAT
Contact Laboratory
GP Routine TAT
Due to extended service pressures please note our TAT have been temporarily extended by 6 weeks beyond the times stated above/below. Please do not contact the lab before this time frame unless there is a clinically urgent need.