Investigation of narcolepsy and other neurological sleep disturbances. Orexin (hypocretin) is a neurotransmitter that regulates wakefulness and appetite. The most common form of narcolepsy, in which the sufferer briefly loses muscle tone (cataplexy), is caused by a lack of orexin in the brain.
Tube
09 (CSF) – Plain CSF
ID
Tests&Tubes0222
Turn Around
Turnaround time stated by Churchill Hospital: 42 working days (8 to 9 weeks).
Send to
Blood Sciences LGI
(Test referred to: the Churchill Hospital)
Oxford.
Contact
For further details please contact Ä¢¹½tvÊÓƵ Pathology customer services: [email protected].
Collection Con
2 mL CSF required. Instructions to lab: Store in fridge before dispatch. If volume is sufficient, retain a frozen aliquot in the lab for safekeeping.
Sample REQ
CSF
Ref. Range Notes
Values >200 pg/mL are seen in healthy controls. Values of <110 pg/mL are mainly seen in patients with narcolepsy with cataplexy. Values between 110 to 200 pg/mL can be seen in patients with other neurological diseases associated with sleep disturbances.
Units
pg/mL