This test detects the present of serum immunoglobulin kappa and lambda free light chains, and expresses these as a ratio, the sFLC ratio.
Tube
Serum Gel
ID
12811
Availability
Weekdays
Additional Information
Measurement of the kappa:lambda ratio provides a numerical indicator of clonality (Tumours produce monoclonal excess of only one of the light chain types, often with bone marrow suppression of the alternative light chain, so that the kappa:lambda ratios becomes skewed). A patient with a ‘kappa’ paraprotein (eg IgG Kappa, Kappa LCMM) will have an increased serum free ligh chain kappa:lambda ratio. A patient with a ‘lambda’ paraprotein with have a decreased serum free light chain kappa:lambda ratio.
Turn Around
7 days
Send to
Ä¢¹½tvÊÓƵ General Infirmary
Clinical Immunology
Old Medical School
Great George Street
Ä¢¹½tvÊÓƵ
LS1 3EX
Collection Con
No restrictions.
Frequency
Daily.
Sample REQ
Blood.
Ref. Range (Male)
As set by Siemens N latext sFLC assay: Free kappa: 6.7 to 22.4 Free Lambda: 8.3 to 27 Kappa:Lambda Ratio: 0.31 to 1.56
Ref. Range (Female)
As set by Siemens N latext sFLC assay: Free kappa: 6.7 to 22.4 Free Lambda: 8.3 to 27 Kappa:Lambda Ratio: 0.31 to 1.56
Ref. Range (Paed)
As set by Siemens N latext sFLC assay: Free kappa: 6.7 to 22.4 Free Lambda: 8.3 to 27 Kappa:Lambda Ratio: 0.31 to 1.56
Ref. Range Notes
(The sFLC kappa:lambda ratio in patients with renal failure do not differ from the reference limits for healthy controls).
Units
mg/L
IP Acute TAT
Contact Laboratory
IP Routine TAT
7 days
GP Acute TAT
Contact Laboratory
GP Routine TAT
7 days