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Trimethylamine is an organic compound with a strong ‘’fishy’’ odour in low concentrations. For the diagnosis of primary and secondary trimethylaminuria (Fish Odour Syndrome).                                                        

Tube

08 (UR) – Urine 24 Hr Chemical Preservative. (Hydrocholric acid preservative required)

ID

Tests&Tubes0249

Additional Information

TMAU is associated with ingestion of certain foods and so it is important to collect this sample at the time of the odour. A dietary ‘choline load’ is recommended before collecting the samples by using foods known to produce the odour e.g. beans, eggs, liver. Please contact the duty biochemist if for more information if required.

Turn Around

6 to 8 weeks once received at referral lab.

Send to

CfLM, St James University Hospital
(Test referred to: Sheffield Children’s Hospital)

Contact

For further details please contact Ä¢¹½tvÊÓƵ Pathology customer services: [email protected].

Advice

Lab staff: full information on all referred tests can be found on the referred tests information database, BSHC-REC-323.

Collection Con

Ideally, 24h collection collected into 10 mL 6M HCl. Can send 20 mL plain urine in a Universal which can be acidified in the Blood Sciences lab. Instructions to lab: contact Duty Biochemist if sample requires acidification to pH < 2. Send 20 mL. Store sample frozen at -80C
Minimum volume: 10 mL urine

Sample Type

Urine

Ref. Range Notes

Free TMA/ creat ratio: < 7.7 µmol/mmol crt
TMA-N-Oxide / creat ratio: < 119 µmol/mmol crt
% N-Oxidation: > 94%
Additional interpretation will be provided on the report.